Sulforaphane Enhances Proteasome Activity through Upregulation of Hsp27
نویسندگان
چکیده
منابع مشابه
Sulforaphane enhances cisplatin sensitivity in human osteosarcoma cells through upregulation of p53-p21 pathway by enhancing G1 arrest
Background: Cisplatin (CisPt) resistance is one of the major problems for the treatment of osteosarcoma. The natural compound sulforaphane (SFN) are reported to have antitumor activity in many cancers. However, its effect to influence CisPt resistance in osteosarcoma cells has not examined. In this study, we intended to investigate the combined effects of SFN and CisPt in osteosarcoma cells and...
متن کاملUpregulation of proteasome activity rescues cardiomyocytes following pulse treatment with a proteasome inhibitor.
This study examined the hypothesis that cardiomyocyte metabolism is inherently linked to the Ubiquitin Proteasome System. Rat neonatal ventricular cardiomyocytes were pulse-treated with 5 αM lactacystin for 30 min, resulting in 95% loss of proteasome activity, and then maintained in culture for up to 24 h. Pulse-treatment resulted in 36% decrease in cardiomyocyte mitochondrial reductase activit...
متن کاملS100A7 enhances mammary tumorigenesis through upregulation of inflammatory pathways.
S100A7/psoriasin, a member of the epidermal differentiation complex, is widely overexpressed in invasive estrogen receptor (ER)α-negative breast cancers. However, it has not been established whether S100A7 contributes to breast cancer growth or metastasis. Here, we report the consequences of its expression on inflammatory pathways that impact breast cancer growth. Overexpression of human S100A7...
متن کاملIbuprofen enhances TRAIL-induced apoptosis through DR5 upregulation.
Numerous human chemoprevention studies have demonstrated that non-steroidal anti-inflammatory drugs (NSAIDs) possess chemopreventive effects against a variety of malignant tumors. However, there have been many clinical studies on aspirin, but not ibuprofen, even though ibuprofen is one of the most clinically and safely used NSAIDs showing potent anti-inflammatory effects. Moreover, we reported ...
متن کاملTranscriptional upregulation of BAG3 upon proteasome inhibition.
Proteasome inhibitors exhibit antitumoral activity against malignancies of different histology. Emerging evidence indicates that antiapoptotic factors may also accumulate as a consequence of exposure to these drugs, thus it seems plausible that activation of survival signaling cascades might compromise their antitumoral effects. Bcl-2-associated athanogene (BAG) family proteins are characterize...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: The FASEB Journal
سال: 2010
ISSN: 0892-6638,1530-6860
DOI: 10.1096/fasebj.24.1_supplement.464.2